Overview

  • Product name
  • Description
    Rabbit polyclonal to UTF1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the central region of Human UTF1, conjugated to KLH

  • Positive control
    • NCI-H460 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab65453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 35 kDa (predicted molecular weight: 37 kDa).
ELISA 1/1000.

Target

  • Function
    Acts as a transcriptional coactivator of ATF2.
  • Domain
    The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Form
    UTF1 is a transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. Upon activation by Oct-3/4, UTF1 may be responsible for the rapid proliferation and tumorigenic properties of embryonic stem cells. Sox2 is also part of the Oct-3/4-containing complex able to bind the regulatory region of UTF1. UTF1 acts as a transcriptional coactivator of ATF2 and it binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
  • Alternative names
    • hUTF 1 antibody
    • hUTF1 antibody
    • Undifferentiated embryonic cell transcription factor 1 antibody
    • UTF 1 antibody
    • UTF1 antibody
    • UTF1_HUMAN antibody
    see all

Images

References

ab65453 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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