Overview

  • Product name
  • Description
    Mouse polyclonal to UXT
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human UXT (amino acids 1-169; NP_705582.1).

  • Positive control
    • Jurkat cell lysate; UXT transfected 293T cell lysate; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab168678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 19 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.
  • Tissue specificity
    Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.
  • Sequence similarities
    Belongs to the UXT family.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Androgen receptor trapped clone 27 protein antibody
    • ART 27 antibody
    • ART-27 antibody
    • OTTHUMP00000023226 antibody
    • OTTHUMP00000023227 antibody
    • Protein UXT antibody
    • SKP2 associated alpha PFD 1 antibody
    • STAP1 antibody
    • Ubiquitously expressed prefoldin like chaperone antibody
    • Ubiquitously expressed transcript antibody
    • Ubiquitously expressed transcript protein antibody
    • Uxt antibody
    • UXT_HUMAN antibody
    see all

Images

  • Anti-UXT antibody (ab168678) at 1 µg/ml + Jurkat cell lysate at 50 µg
    Developed using the ECL technique

    Predicted band size : 19 kDa
  • All lanes : Anti-UXT antibody (ab168678) at 1 µg/ml

    Lane 1 : UXT transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique

    Predicted band size : 19 kDa
  • Immunofluorescent analysis of HeLa cells labeling UXT with ab168678 at 10µg/ml.

References

ab168678 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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