Recombinant Anti-VANGL1 antibody [EPR12415] (ab176575)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR12415] to VANGL1
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-VANGL1 antibody [EPR12415]
See all VANGL1 primary antibodies -
Description
Rabbit monoclonal [EPR12415] to VANGL1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide within Human VANGL1 aa 200-300 (internal sequence) (Cysteine residue). The exact sequence is proprietary.
Database link: Q8TAA9 -
Positive control
- MCF7, HeLa, Jurkat and MOLT4 cell lysates.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR12415 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab176575 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/5000. Predicted molecular weight: 60 kDa.
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Notes |
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WB
1/1000 - 1/5000. Predicted molecular weight: 60 kDa. |
Target
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Tissue specificity
Accordiing to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary. -
Involvement in disease
Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis).
Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. -
Sequence similarities
Belongs to the Vang family. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 81839 Human
- Entrez Gene: 229658 Mouse
- Entrez Gene: 690366 Rat
- Omim: 610132 Human
- SwissProt: Q8TAA9 Human
- SwissProt: Q80Z96 Mouse
- Unigene: 515130 Human
- Unigene: 118004 Mouse
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Alternative names
- ANGL planar cell polarity protein 1 antibody
- KAI1 C-terminal interacting tetraspanin antibody
- KITENIN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab176575 has not yet been referenced specifically in any publications.