The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
The vascular endothelium serves as an important autocrine and paracrine organ and maintains vascular homeostasis. Alteration of the vascular endothelium is a primary event in the pathogenesis of vascular diseases and is a critical target for preventing or slowing the progression of vascular disease. Endothelial dysfunction is recognized as the initial step in the atherosclerotic process and is well described in patients with diabetes and atherosclerosis.