• Product name
    Anti-Vav proteins antibody
    See all Vav proteins primary antibodies
  • Description
    Rabbit polyclonal to Vav proteins
  • Tested applications
    Suitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids 172-176 of Human Vav proteins

  • Positive control
    • Jurkat or THP1 cell lysate.



Our Abpromise guarantee covers the use of ab92890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IP: 2 µg.
    WB: 1/1000. Predicted molecular weight: 98 kDa (VAV1 & VAV3). 101 kDa (VAV2)

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.
    • Cellular localization
      Cytoplasmic and Plasma membrane VAV1, Cytoplasm - VAV2 & VAV3
    • Database links
    • Alternative names
      • 2810040F13Rik antibody
      • A530094I06Rik antibody
      • AA986410 antibody
      • AI847175 antibody
      • FLJ40431 antibody
      • GDP/GTP exchange factor VAV2 antibody
      • Guanine nucleotide exchange factor VAV2 antibody
      • Guanine nucleotide exchange factor VAV3 antibody
      • MGC27838 antibody
      • Oncogene VAV antibody
      • Oncogene VAV1 antibody
      • Oncogene VAV2 antibody
      • Oncogene VAV3 antibody
      • p95 antibody
      • p95vav antibody
      • Protein vav 1 antibody
      • Protein vav 2 antibody
      • Protein vav 3 antibody
      • Proto oncogene vav antibody
      • RGD1565941 antibody
      • VAV antibody
      • vav 1 guanine nucleotide exchange factor antibody
      • Vav 1 oncogene antibody
      • vav 2 guanine nucleotide exchange factor antibody
      • Vav 2 oncogene antibody
      • vav 3 guanine nucleotide exchange factor antibody
      • Vav 3 oncogene antibody
      • vav-T antibody
      • VAV1 oncogene antibody
      • VAV2 oncogene antibody
      • VAV3 oncogene antibody
      see all

    Anti-Vav proteins antibody images

    • Immunoprecipitation of VAV proteins from 500µg of Jurkat (Lane 1) and THP1 (Lane 2) cell lysates, using 2µg of ab92890.
    • All lanes : Anti-Vav proteins antibody (ab92890) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate at 3 µg
      Lane 2 : Jurkat cell lysate at 10 µg
      Lane 3 : Jurkat cell lysate at 30 µg

      Predicted band size : 98 kDa

    References for Anti-Vav proteins antibody (ab92890)

    ab92890 has not yet been referenced specifically in any publications.

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