Overview

  • Product name
  • Description
    Goat polyclonal to VAV2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    ETEAKYYRTLEDIEC

    , corresponding to Internal sequence amino acids 208-221 of Human VAV2.

  • General notes
    GenBank Accession Number – NP_003362. LocusLink ID - 7410 (human); 22325 (mouse). Gene Ontology terms - guanyl-nucleotide exchange factor activity; intracellular signaling cascade; diacylglycerol binding.

Properties

Applications

Our Abpromise guarantee covers the use of ab4549 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    Peptide ELISA: antibody detection limit dilution >1/32000.
    WB: Use at a concentration of 1 - 1.5 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 100 kDa).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
    • Tissue specificity
      Widely expressed.
    • Sequence similarities
      Contains 1 CH (calponin-homology) domain.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 phorbol-ester/DAG-type zinc finger.
      Contains 1 SH2 domain.
      Contains 2 SH3 domains.
    • Information by UniProt
    • Database links
    • Alternative names
      • Guanine nucleotide exchange factor VAV2 antibody
      • Oncogene VAV2 antibody
      • Protein vav 2 antibody
      • VAV 2 antibody
      • Vav 2 oncogene antibody
      • VAV-2 antibody
      • VAV2 antibody
      • VAV2 oncogene antibody
      • VAV2_HUMAN antibody
      see all

    Images



    • Predicted band size : 100 kDa


      ab4549 staining (1.5µg/ml) of 293 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

    References

    ab4549 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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