Overview

  • Product name
  • Description
    Goat polyclonal to VAV3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Synthetic peptide:

    CSGEQGTLKLPEK

    , corresponding to internal sequence amino acids 567-578 of Human VAV3

  • Positive control
    • Human Skin Human Spleen Human bone marrow lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab118904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 98 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
  • Sequence similarities
    Contains 1 CH (calponin-homology) domain.
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 SH2 domain.
    Contains 2 SH3 domains.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ40431 antibody
    • Guanine nucleotide exchange factor VAV3 antibody
    • Protein vav 3 antibody
    • Protein vav3 antibody
    • RGD1565941 antibody
    • VAV 3 antibody
    • Vav 3 guanine nucleotide exchange factor antibody
    • VAV 3 oncogene antibody
    • VAV 3 protein antibody
    • VAV-3 antibody
    • Vav3 antibody
    • VAV3 oncogene antibody
    • VAV3 protein antibody
    • VAV3_HUMAN antibody
    see all

Images

  • Immunohistochemistry analysis (formalin-fixed, paraffin-embedded)of Human Skin stained with ab118904 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Immunohistochemistry analysis (formalin-fixed, paraffin-embedded)of Human Spleen stained with ab118904 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-VAV3 antibody (ab118904) at 0.3 µg/ml + Human bone marrow lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 98 kDa


    Exposure time : 1 hour

References

ab118904 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab118904.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up