The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesICC/IF: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Inhib: Use at an assay dependent dilution. Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures.
Is unsuitable for IHC-P.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Tissue specificityExpressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
References for Anti-VCAM1 antibody [1.BB.619] (ab61993)
This product has been referenced in:
Ratliff BB et al. Mesenchymal stem cells, used as bait, disclose tissue binding sites: a tool in the search for the niche? Am J Pathol177:873-83 (2010).
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