Overview

  • Product nameAnti-VCAM1 antibody [1.BB.619]See all VCAM1 primary antibodies ...
  • Description
    Rat monoclonal [1.BB.619] to VCAM1
  • SpecificityThis antibody recognizes all known isoforms of mouse VCAM1.
  • Tested applicationsInhibition Assay, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Full length mouse VCAM1 protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab61993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Inhibition Assay
IP
ICC/IF
  • Application notesICC/IF: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    Inhib: Use at an assay dependent dilution. Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures.

    Is unsuitable for IHC-P.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
    • Tissue specificityExpressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    • Sequence similaritiesContains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • DomainEither the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    • Post-translational
      modifications
      Sialoglycoprotein.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD 106 antibody
      • CD106 antibody
      • CD106 Antigen antibody
      • DKFZp779G2333 antibody
      • INCAM 100 antibody
      • INCAM-100 antibody
      • L1CAM antibody
      • MGC99561 antibody
      • V-CAM 1 antibody
      • Vascular Cell Adhesion Molecule 1 antibody
      • Vascular cell adhesion protein 1 antibody
      • VCAM 1 antibody
      • VCAM-1 antibody
      • VCAM1 antibody
      • VCAM1_HUMAN antibody
      see all

    References for Anti-VCAM1 antibody [1.BB.619] (ab61993)

    This product has been referenced in:
    • Ratliff BB  et al. Mesenchymal stem cells, used as bait, disclose tissue binding sites: a tool in the search for the niche? Am J Pathol 177:873-83 (2010). Inhibition Assay . Read more (PubMed: 20558574) »

    See 1 Publication for this product

    Product Wall

    Thanks you for your email.
    In my previous email there is a correction about the expiry date. The expiry date should be read as 25-08-2012.
    I have asked lab to release the immunogen information of these antibodies; I will be able to send the a...

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    Expiration date: 25-04-2012
    I am very pleased to hear you would like to use ab18407 and ab18541 in ICC/IF and send us an image of your results.
    This code will give you 1 free [PRIMARY ANTIBODY] before the expiration date. To redeem this offer...

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    Thank you for your enquiry. There are some references for use of VCAM-1 in Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures: -A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"