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Overview

  • Product nameAnti-VCAM1 antibody [1.BB.619]See all VCAM1 primary antibodies ...
  • Description
    Rat monoclonal [1.BB.619] to VCAM1
  • SpecificityThis antibody recognizes all known isoforms of mouse VCAM1.
  • Tested applicationsInhibition Assay, IP, ICC/IF more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Full length mouse VCAM1 protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab61993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Inhibition Assay
IP
ICC/IF
  • Application notesICC/IF: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    Inhib: Use at an assay dependent dilution. Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures.

    Is unsuitable for IHC-P.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
    • Tissue specificityExpressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    • Sequence similaritiesContains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • DomainEither the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    • Post-translational
      modifications      Sialoglycoprotein.
    • Cellular localizationMembrane.

      • Target information above from: UniProt accession P19320 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          CD 106 antibodyCD106 antibodyCD106 Antigen antibody
          DKFZp779G2333 antibodyINCAM 100 antibodyINCAM-100 antibodyL1CAM antibodyMGC99561 antibodyV-CAM 1 antibodyVascular Cell Adhesion Molecule 1 antibodyVascular cell adhesion protein 1 antibodyVCAM 1 antibodyVCAM-1 antibodyVCAM1 antibodyVCAM1_HUMAN antibody
        see all

      References for Anti-VCAM1 antibody [1.BB.619] (ab61993)

      This product has been referenced in:
      • Ratliff BB  et al. Mesenchymal stem cells, used as bait, disclose tissue binding sites: a tool in the search for the niche? Am J Pathol 177:873-83 (2010). Inhibition Assay . Read more (PubMed: 20558574) »

      See 1 Publication for this product

      Publishing research using ab61993 ? Please let us know so that we can cite the reference in this datasheet

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      Submit an Abreview for ab61993 Submit a Question for ab61993

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      Thank you so much for your email. I would like to ask you a question.

      I have to target 3 proteins in my Mouse Brain Enothelial cell line (bEnd.3), which are E-selectin (CD62E), VCAM and ICAM.

      I have chosen ab2497 for E-selectin , ab6...

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      Thanks you for your email.
      In my previous email there is a correction about the expiry date. The expiry date should be read as 25-08-2012.
      I have asked lab to release the immunogen information of these antibodies; I will be able to send the answ...

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      Provide the discount code for ab18407 and ab18541

      Expiration date: 25-04-2012
      I am very pleased to hear you would like to use ab18407 and ab18541 in ICC/IF and send us an image of your results.
      This code will give you 1 free [PRIMARY ANTIBODY] before the expiration date. To redeem this offer, p...

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      I have a question about VCAM1 antibody [1.BB.619], ab61993. Could you please provide information about "Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures. "?

      Thank you for your enquiry. There are some references for use of VCAM-1 in Inhibition of lymphopoiesis in Whitlock-Witte long term marrow cultures: -A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte pre...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"