Overview

  • Product nameAnti-VCAM1 antibody [M/K-2] (FITC)See all VCAM1 primary antibodies ...
  • Description
    Rat monoclonal [M/K-2] to VCAM1 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • SpecificityThis antibody is specific for VCAM1.
  • Tested applicationsICC/IF, IP, Functional Studies, Flow Cyt more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

Properties

Applications

Our Abpromise guarantee covers the use of ab24853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF
IP
Functional Studies
Flow Cyt
  • Application notesFlow Cyt: Use 1µg for 106 cells.
    FuncS (Blockage of lymphocyte adhesion in Whitlock-Witte long-term bone marrow cultures & Inhibition of lymphopoiesis in Whitlock-Witte cultures): Use at an assay dependent dilution.
    IF: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
    • Tissue specificityExpressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    • Sequence similaritiesContains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • DomainEither the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    • Post-translational
      modifications
      Sialoglycoprotein.
    • Cellular localizationMembrane.
    • Target information above from: UniProt accession P19320 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • CD 106 antibody
      • CD106 antibody
      • CD106 Antigen antibody
      • DKFZp779G2333 antibody
      • INCAM 100 antibody
      • INCAM-100 antibody
      • L1CAM antibody
      • MGC99561 antibody
      • V-CAM 1 antibody
      • Vascular Cell Adhesion Molecule 1 antibody
      • Vascular cell adhesion protein 1 antibody
      • VCAM 1 antibody
      • VCAM-1 antibody
      • VCAM1 antibody
      • VCAM1_HUMAN antibody
      see all

    Anti-VCAM1 antibody [M/K-2] (FITC) images

    • ab24853 staining mouse (Balb/c) bone marrow cells by flow cytometry. 1µg of antibody was used for 106 cells.

    References for Anti-VCAM1 antibody [M/K-2] (FITC) (ab24853)

    This product has been referenced in:
    • Ma M  et al. Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells 28:1465-75 (2010). Flow Cyt ; Mouse . Read more (PubMed: 20629173) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"