Anti-VCAM1 antibody [MVCAM.A(429)] (Biotin) (ab27561)

Overview

  • Product nameAnti-VCAM1 antibody [MVCAM.A(429)] (Biotin)See all VCAM1 primary antibodies ...
  • Description
    Rat monoclonal [MVCAM.A(429)] to VCAM1 (Biotin)
  • ConjugationBiotin
  • Tested applicationsFlow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation (Mouse) - stromal cell line PA6.

  • General notes


    This antibody is reported to partially block VCAM1 mediated functions.

Properties

Applications

Our Abpromise guarantee covers the use of ab27561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Neat - 1/10 working dilution. Use 10µl of this for a million cells in 100µl.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
    • Tissue specificityExpressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    • Sequence similaritiesContains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • DomainEither the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    • Post-translational
      modifications
      Sialoglycoprotein.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD 106 antibody
      • CD106 antibody
      • CD106 Antigen antibody
      • DKFZp779G2333 antibody
      • INCAM 100 antibody
      • INCAM-100 antibody
      • L1CAM antibody
      • MGC99561 antibody
      • V-CAM 1 antibody
      • Vascular Cell Adhesion Molecule 1 antibody
      • Vascular cell adhesion protein 1 antibody
      • VCAM 1 antibody
      • VCAM-1 antibody
      • VCAM1 antibody
      • VCAM1_HUMAN antibody
      see all

    References for Anti-VCAM1 antibody [MVCAM.A(429)] (Biotin) (ab27561)

    ab27561 has not yet been referenced specifically in any publications.

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