Overview

  • Product nameAnti-VDAC1/Porin antibody
    See all VDAC1/Porin primary antibodies
  • Description
    Rabbit polyclonal to VDAC1/Porin
  • SpecificityThe immunogen used in producing this product has considerable homology (60-70%) with the human, rat, and mouse VDAC isoforms VDAC2 and VDAC3.
  • Tested applicationsDot Blotmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Rabbit, Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Human VDAC1/Porin aa 152-169 conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    GYQMNFETAKSRVTQSNFA

Properties

Applications

Our Abpromise guarantee covers the use of ab10523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot Blot
  • Application notesDot: 1/2000, determined using rat liver mitochondria extract.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
    • Tissue specificityHeart, liver and skeletal muscle.
    • Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
    • DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
    • Cellular localizationMitochondrion outer membrane. Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • N2441 antibody
      • OMP2 antibody
      • POR1 antibody
      • hVDAC1 antibody
      • MGC111064 antibody
      • Mitochondrial Porin antibody
      • Outer mitochondrial membrane protein porin 1 antibody
      • Plasmalemmal porin antibody
      • Porin 31HL antibody
      • Porin 31HM antibody
      • VDAC antibody
      • VDAC-1 antibody
      • Vdac1 antibody
      • VDAC1_HUMAN antibody
      • Voltage dependent anion channel 1 antibody
      • Voltage dependent anion selective channel protein 1 antibody
      • Voltage-dependent anion-selective channel protein 1 antibody
      • YNL055C antibody
      • YNL2441C antibody
      see all

    References for Anti-VDAC1/Porin antibody (ab10523)

    ab10523 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"