Anti-VDAC2 antibody (ab37985)
Key features and details
- Goat polyclonal to VDAC2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-VDAC2 antibody
See all VDAC2 primary antibodies -
Description
Goat polyclonal to VDAC2 -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rabbit, Cow, Dog, Pig -
Immunogen
Synthetic peptide corresponding to Human VDAC2 aa 250 to the C-terminus (C terminal).
Database link: P45880 -
Positive control
- WB: Human cerebellum cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab37985 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (7) |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa).
1 hour primary incubation is recommended for this product. |
Notes |
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WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa). 1 hour primary incubation is recommended for this product. |
Target
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Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. -
Tissue specificity
Expressed in all tissues examined. -
Sequence similarities
Belongs to the eukaryotic mitochondrial porin family. -
Domain
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. -
Cellular localization
Mitochondrion outer membrane. - Information by UniProt
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Database links
- Entrez Gene: 282120 Cow
- Entrez Gene: 479255 Dog
- Entrez Gene: 7417 Human
- Entrez Gene: 397659 Pig
- Omim: 193245 Human
- SwissProt: P45880 Human
- SwissProt: Q9MZ15 Pig
- Unigene: 355927 Human
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Alternative names
- B-36 vdac antibody
- FLJ23841 antibody
- hVDAC2 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (20)
ab37985 has been referenced in 20 publications.
- Battaglia AM et al. Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells. Front Oncol 12:868351 (2022). PubMed: 35433479
- Singulani MP et al. Impairment of PGC-1a-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease. Exp Gerontol 133:110882 (2020). PubMed: 32084533
- Li D et al. Quercetin Alleviates Ferroptosis of Pancreatic ß Cells in Type 2 Diabetes. Nutrients 12:N/A (2020). PubMed: 32992479
- Cioni JM et al. Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons. Cell 176:56-72.e15 (2019). PubMed: 30612743
- Dadsena S et al. Ceramides bind VDAC2 to trigger mitochondrial apoptosis. Nat Commun 10:1832 (2019). PubMed: 31015432