1/200 - 1/400. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
Endothelial tissues and brain.
Contains 5 cadherin domains.
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.