Overview

Description

  • Nature
    Recombinant
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab27462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168)

  • Purity
    > 90 % n/a.

  • Form
    Lyophilised
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 7B 4
    • 7B4
    • 7B4 antigen
    • CADH5_HUMAN
    • Cadherin 5
    • Cadherin 5 type 2
    • Cadherin 5, type 2 (vascular endothelium)
    • Cadherin 5, type 2, VE cadherin (vascular epithelium)
    • cadherin, vascular endothelial
    • cadherin, vascular endothelial, 1
    • Cadherin-5
    • Cadherin5
    • CD 144
    • CD144
    • CD144 antigen
    • CDH 5
    • CDH5
    • CDH5 protein
    • Endothelial specific cadherin
    • FLJ17376
    • OTTHUMP00000174777
    • Vascular endothelial cadherin
    • Vascular epithelium cadherin
    • VE Cad
    • VE-cadherin
    • VEC
    see all
  • Function
    Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
  • Tissue specificity
    Endothelial tissues and brain.
  • Sequence similarities
    Contains 5 cadherin domains.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
  • Cellular localization
    Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • Information by UniProt

References

ab27462 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab27462.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up