Overview

  • Product nameAnti-VEGF Receptor 3 antibody
    See all VEGF Receptor 3 primary antibodies
  • Description
    Mouse monoclonal to VEGF Receptor 3
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Recombinant fragment: ITEESHVIDT GDSLSISCRG QHPLEWAWPG AQEAPATGDK DSEDTGVVRD CEGTDARPYC KVLLLHEVHA NDTGSYVCYY KYIKARIEGT TAASSYVFVR, corresponding to amino acids 34-133 of Human VEGF Receptor 3 (NP_002011) with a proprietary tag.

  • Positive control
    • MES-SA/Dx5 cell lysate. Partial tagged recombinant Human VEGF Receptor 3 (Immunogen).

Properties

Applications

Our Abpromise guarantee covers the use of ab89501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 146 kDa.
ELISA Use at an assay dependent dilution. Detection limit for recombinant tagged VEGF Receptor 3 is approximately 0.3ng/ml when used as a capture antibody.

Target

  • FunctionReceptor for VEGFC. Has a tyrosine-protein kinase activity.
  • Tissue specificityPlacenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
  • Involvement in diseaseDefects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
    Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 2.7.10.1 antibody
    • flt 4 antibody
    • FLT-4 antibody
    • FLT4 antibody
    • FLT41 antibody
    • Fms related tyrosine kinase 4 antibody
    • Fms-like tyrosine kinase 4 antibody
    • LMPH1A antibody
    • PCL antibody
    • Soluble VEGFR3 variant 1 antibody
    • Soluble VEGFR3 variant 2 antibody
    • Soluble VEGFR3 variant 3 antibody
    • Tyrosine protein kinase receptor FLT4 antibody
    • Tyrosine-protein kinase receptor FLT4 antibody
    • Vascular endothelial growth factor receptor 3 antibody
    • Vascular endothelial growth factor receptor 3 precursor antibody
    • VEGF R3 antibody
    • VEGFR 3 antibody
    • VEGFR-3 antibody
    • VEGFR3 antibody
    • VGFR3_HUMAN antibody
    see all

Anti-VEGF Receptor 3 antibody images

  • Anti-VEGF Receptor 3 antibody (ab89501) at 5 µg/ml + Partial tagged recombinant Human VEGF Receptor 3 protein at 0.2 µg

    Predicted band size : 146 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-VEGF Receptor 3 antibody (ab89501) at 5 µg/ml + MES-SA/Dx5 cell lysate at 50 µg

    Predicted band size : 146 kDa
    Observed band size : 155 kDa (why is the actual band size different from the predicted?)
  • Detection limit for recombinant tagged VEGF Receptor 3 is approximately 0.3ng/ml as a capture antibody.

References for Anti-VEGF Receptor 3 antibody (ab89501)

ab89501 has not yet been referenced specifically in any publications.

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