Anti-VEGFB 167 antibody [MM0008-7B43] (ab51867)

Overview

  • Product nameAnti-VEGFB 167 antibody [MM0008-7B43]
  • Description
    Mouse monoclonal [MM0008-7B43] to VEGFB 167
  • Specificityab51867 detects both VEGFB 167 and 186 isoforms. No cross reactivity is shown with VEGF, VEGFC and VEGFD.
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human VEGFB 167 recombinant protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab51867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Predicted molecular weight: 22 kDa.
IHC-P 1/25 - 1/100.

Target

  • RelevanceVascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis.
  • Cellular localizationSecreted protein. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
  • Database links
  • Alternative names
    • Vascular endothelial growth factor B antibody
    • VEGF B antibody
    • VEGF related factor antibody
    • VEGFL antibody
    • Vrf antibody
    see all

Anti-VEGFB 167 antibody [MM0008-7B43] images

  • ab51867 at 1/100 dilution, staining VEGFB 167 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

References for Anti-VEGFB 167 antibody [MM0008-7B43] (ab51867)

ab51867 has not yet been referenced specifically in any publications.

Product Wall

I just checked the database and it seems that we had an error when the image was added. Please rest assured that the product was tested in IHC-P and the image is correct. The error was the IHC-Fr application, which was wrongly chosen. It should be ...

Read More
Application Western blot
Sample Cow Tissue lysate - whole (Corpora lutea)
Loading amount 60 µg
Specification Corpora lutea
Gel Running Conditions Reduced Denaturing (Precasted Gel Invitrogen 12% Bis-Tris)
Blocking step BSA as blocking agent for 18 hour(s) and 0 minute(s) · Concentration: 2% · Temperature: 4°C
Username

Abcam user community

Verified customer

Submitted Jul 14 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"