Overview

  • Product nameAnti-VEGFC antibody [9/E7]
    See all VEGFC primary antibodies
  • Description
    Mouse monoclonal [9/E7] to VEGFC
  • Tested applicationsSuitable for: IHC-P, WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment (His-tag) corresponding to Human VEGFC aa 103-215.
    Database link: P49767

Properties

Applications

Our Abpromise guarantee covers the use of ab106512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2 - 10 µg/ml.
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 47 kDa.
IHC-Fr Use a concentration of 2 - 10 µg/ml.

Target

  • FunctionGrowth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • Tissue specificitySpleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
  • Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
  • Post-translational
    modifications
    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Flt 4L antibody
    • Flt4 ligand antibody
    • FLT4 ligand DHM antibody
    • Flt4-L antibody
    • Flt4L antibody
    • Vascular endothelial growth factor C antibody
    • Vascular endothelial growth factor related protein antibody
    • Vascular endothelial growth factor-related protein antibody
    • VEGF C antibody
    • VEGF-C antibody
    • Vegfc antibody
    • VEGFC_HUMAN antibody
    • VRP antibody
    see all

Anti-VEGFC antibody [9/E7] images

  • Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.

  • Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue sections labelling VEGFC with ab106512.

References for Anti-VEGFC antibody [9/E7] (ab106512)

ab106512 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"