Overview

  • Product name
    VEGFR2 Kinase Inhibitor I
  • Description
    Highly selective, cell-permeable indolin-2-one class receptor tyrosine kinase (RTK) inhibitor for vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1).
  • Alternative names
    • 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, ethyl ester
    • IN1018
    • SU 5408
    • VEGF Receptor 2 Kinase Inhibitor I
  • Biological description

    Highly selective, cell-permeable inhibitor of VEGFR2 kinase. Little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor.

  • Purity
    > 95%

Properties

  • Chemical name
    (Z)-3-[[2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl]methylidenyl]indolin-2-one
  • Molecular weight
    310.40
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H18N2O3
  • CAS Number
    15966-93-5
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Sun L  et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem 41:2588-603 (1998). Read more (PubMed: 9651163) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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