Anti-VIP antibody (ab8556)
Key features and details
- Rabbit polyclonal to VIP
- Suitable for: IHC-P, IP, IHC-FoFr, WB, ICC
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-VIP antibody
See all VIP primary antibodies -
Description
Rabbit polyclonal to VIP -
Host species
Rabbit -
Specificity
This antibody reacts with a 3 kD vasointestinal peptide (VIP) localized in nerve fibers in the central and peripheral nervous system. The VIP producing tumors are usually neuroblastomas of endocrine tumors in the pancreas. -
Tested applications
Suitable for: IHC-P, IP, IHC-FoFr, WB, ICCmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Full length protein corresponding to Human VIP.
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General notes
This antibody detects ganglion cells in both the superficial and deep plexus of the wall of the small bowel in human.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 0.01% PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
After solid-phase absorption this antibody is filtered through a 0.22 µm filter, vialed and lyophilized. -
Primary antibody notes
This antibody detects ganglion cells in both the superficial and deep plexus of the wall of the small bowel in human. -
Clonality
Polyclonal -
Isotype
IgG -
Light chain type
unknown -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8556 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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IHC-FoFr |
Use at an assay dependent concentration. PubMed: 29751824
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 19 kDa.
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ICC |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
IHC-FoFr
Use at an assay dependent concentration. PubMed: 29751824 |
WB
Use at an assay dependent concentration. Predicted molecular weight: 19 kDa. |
ICC
Use at an assay dependent concentration. |
Target
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Function
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation. -
Sequence similarities
Belongs to the glucagon family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 7432 Human
- Entrez Gene: 22353 Mouse
- Entrez Gene: 117064 Rat
- Omim: 192320 Human
- SwissProt: P01282 Human
- SwissProt: P32648 Mouse
- SwissProt: P01283 Rat
- Unigene: 53973 Human
see all -
Alternative names
- Peptide histidine methioninamide 27 antibody
- Peptide histidine valine 42 antibody
- PHM27 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (12)
ab8556 has been referenced in 12 publications.
- Erendor F et al. Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Ther 28:130-141 (2021). PubMed: 32733091
- Cheng CY et al. Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells. Oncogenesis 9:38 (2020). PubMed: 32205838
- Li S et al. VIP activates primordial follicles of rat through ERK-mTOR pathway during in tissue culture. Reproduction N/A:N/A (2019). PubMed: 30817320
- Maiti AK et al. Colonic levels of vasoactive intestinal peptide decrease during infection and exogenous VIP protects epithelial mitochondria against the negative effects of IFN? and TNFa induced during Citrobacter rodentium infection. PLoS One 13:e0204567 (2018). PubMed: 30252907
- Valadas JS et al. ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson's Disease. Neuron 98:1155-1169.e6 (2018). PubMed: 29887339