Mouse, Rat, Human Predicted to work with:
Rabbit, Horse, Chicken, Turkey, Pig, Chimpanzee, Rhesus monkey, Opossum, Chinese Hamster, Orangutan, Zebra finch, Loxodonta Africana (African bush elephant)
Synthetic peptide, corresponding to a region within amino acids 165-215 of Human Viperin (NP_542388.2).
Human brain, Mouse brain and Rat brain lysates, Human rectum tissue
Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 3 - 5 µg/ml. Predicted molecular weight: 42 kDa.
Use a concentration of 5 µg/ml.
FunctionInvolved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.
Sequence similaritiesBelongs to the RSAD2 family.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus. Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28.
Human rectum tissue probed with ab121042 at a concentration of 5 ug/ml.
References for Anti-Viperin antibody (ab121042)
This product has been referenced in:
Tateda K et al. The suppression of TRIM21 and the accumulation of IFN-a play crucial roles in the pathogenesis of osteonecrosis of the femoral head. Lab Invest92:1318-29 (2012).
Read more (PubMed: 22825687) »