Anti-Vitamin B9 / Folic acid antibody [B762F] (ab38244)

Overview

  • Product nameAnti-Vitamin B9 / Folic acid antibody [B762F]
  • Description
    Mouse monoclonal [B762F] to Vitamin B9 / Folic acid
  • SpecificityThis antibody reacts with free folic acid.
  • Tested applicationsSuitable for: ELISAmore details
  • Immunogen

    Chemical/ Small Molecule, Folic acid conjugated to BSA

Properties

Applications

Our Abpromise guarantee covers the use of ab38244 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • RelevanceFolic acid and Folate (the anion form) are forms of a water-soluble B vitamin. These occur naturally in food and can also be taken as supplements. The biologically active form of folic acid is tetrahydrofolic acid (THFA), which is derived by the 2-step reduction of folate involving dihydrofolate reductase. THFA plays a key role in the transfer of 1-carbon units (such as methyl, methylene, and formyl groups) to the essential substrates involved in the synthesis of DNA, RNA, and proteins. More specifically, THFA is involved with the enzymatic reactions necessary to synthesis of purines, thymidine, and amino acids. Manifestations of folate deficiency thereafter, not surprisingly, would involve impairment of cell division, accumulation of possibly toxic metabolites such as homocysteine, and impairment of methylation reactions involved in the regulation of gene expression, thus increasing neoplastic risks. Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy when a deficiency can result in neural tube defects. In folate deficiency the bone marrow is affected as it is a site of rapid cell turnover. Large red blood cells called megaloblasts are produced, resulting in megaloblastic anemia.
  • Alternative names
    • 5 Methyl THFA antibody
    • 5 Methyltetrahydrofolate antibody
    • Folate antibody
    • Tetrahydrofolate antibody
    • Tetrahydrofolic acid antibody
    • THFA antibody
    see all

References for Anti-Vitamin B9 / Folic acid antibody [B762F] (ab38244)

ab38244 has not yet been referenced specifically in any publications.

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