Specificityab115495 recognizes both the occupied and unoccupied forms of Vitamin D Recptor. It does not cross-react with estrogen and glucocorticoid receptors. In mammals, recognizes a protein of ~53kD which is identified as Vitamin D Receptor (VDR). In avians, VDR appears as a doublet of 58 and 60kD.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 51 kDa.
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionNuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Involvement in diseaseDefects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Nuclear receptor subfamily 1 group I member 1 antibody
Protein phosphatase 1, regulatory subunit 163 antibody
Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
Vitamin D hormone receptor antibody
Vitamin D nuclear receptor variant 1 antibody
Vitamin D receptor antibody
Vitamin D3 receptor antibody
Anti-Vitamin D Receptor antibody images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Vitamin D Receptor antibody (ab115495)
ab115495, at 10 µg/ml, staining Vitamin D Receptor in formalin-fixed, paraffin-embedded Human Colon tissue by Immunohistochemistry using a biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
References for Anti-Vitamin D Receptor antibody (ab115495)
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