Overview

  • Product nameAnti-Vitamin D Receptor antibody
    See all Vitamin D Receptor primary antibodies
  • Description
    Rabbit polyclonal to Vitamin D Receptor
  • Tested applicationsSuitable for: ICC/IF, WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic non phosphopeptide derived from Vitamin D Receptor (Human) around the phosphorylation site of serine 208 (DLSpEE).

  • Positive control
    • Extracts from Jurkat cells, HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab61781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
WB
ELISA
  • Application notesELISA: 1/10000.
    ICC/IF: 1/500 - 1/1000.
    WB: 1/500 - 1/1000. Detects bands of approximately 30 and 48 kDa (predicted molecular weight: 48 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
    • Involvement in diseaseDefects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
    • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1 25 dihydroxyvitamin D3 receptor antibody
      • 1 antibody
      • 1,25 dihydroxyvitamin D3 receptor antibody
      • 1,25-@dihydroxyvitamin D3 receptor antibody
      • 25-dihydroxyvitamin D3 receptor antibody
      • Member 1 antibody
      • NR1I1 antibody
      • Nuclear receptor subfamily 1 group I member 1 antibody
      • PPP1R163 antibody
      • Protein phosphatase 1, regulatory subunit 163 antibody
      • VDR antibody
      • VDR_HUMAN antibody
      • Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
      • Vitamin D hormone receptor antibody
      • Vitamin D nuclear receptor variant 1 antibody
      • Vitamin D receptor antibody
      • Vitamin D3 receptor antibody
      see all

    Anti-Vitamin D Receptor antibody images

    • Immunofluorescence analysis of HeLa cells, using ab61781 antibody at 1/500 dilution in the presence and absence of the immunizing peptide
    • All lanes : Anti-Vitamin D Receptor antibody (ab61781) at 1/500 dilution

      Lane 1 : extracts from Jurkat cells
      Lane 2 : extracts from Jurkat cells with immunizing peptide


      Predicted band size : 48 kDa
      Observed band size : 48 kDa
      Additional bands at : 30 kDa (possible cross reactivity).

    References for Anti-Vitamin D Receptor antibody (ab61781)

    ab61781 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"