Anti-VKORC1 antibody - N-terminal (ab176118)

Overview

  • Product name
    Anti-VKORC1 antibody - N-terminal
    See all VKORC1 primary antibodies
  • Description
    Rabbit polyclonal to VKORC1 - N-terminal
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human VKORC1 (N terminal). The exact sequence is proprietary. NP_076869
    Database link: Q9BQB6

  • Positive control
    • A549 cell lysate and Human lung tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab176118 is affinity chromatography purified via peptide column.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab176118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 18 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Function
    Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.
  • Tissue specificity
    Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas.
  • Involvement in disease
    Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2) [MIM:607473]. VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K.
    Defects in VKORC1 are a cause of coumarin resistance (CMRES) [MIM:122700]; also known as warfarin resistance. Warfarin and other coumarin-type anticoagulants are used to reduce blood viscosity in the treatment of thromboembolic disorders.
  • Sequence similarities
    Belongs to the VKOR family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3-epoxide reductase subunit 1 antibody
    • EDTP308 antibody
    • FLJ00289 antibody
    • IMAGE3455200 antibody
    • MGC2694 antibody
    • MST134 antibody
    • MST576 antibody
    • Phylloquinone epoxide reductase antibody
    • Vitamin K dependent clotting factors deficiency 2 antibody
    • Vitamin K epoxide reductase complex subunit 1 antibody
    • Vitamin K1 2 antibody
    • Vitamin K1 2,3-epoxide reductase subunit 1 antibody
    • Vitamin K1 epoxide reductase (warfarin sensitive) antibody
    • VKCFD2 antibody
    • VKOR antibody
    • VKOR1_HUMAN antibody
    • VKORC1 antibody
    see all

Images

  • Immunohistochemical analysis of Human lung tissue labeling VKORC1  with ab176118 at 2.5 μg/ml.

  • Anti-VKORC1 antibody - N-terminal (ab176118) at 1 µg/ml + A549 cell lysate at 15 µg
    Developed using the ECL technique

    Predicted band size : 18 kDa

References

ab176118 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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