Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-QPNVDTRQKQ
    • Amino acids
      20 to 29

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-VPS25 antibody (ab42500)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • Dermal papilla derived protein 9
    • Dermal papilla-derived protein 9
    • DERP9
    • EAP20
    • ELL associated protein of 20 kDa
    • ELL-associated protein of 20 kDa
    • ESCRT-II complex subunit VPS25
    • FAP20
    • HGNC:28122
    • hVps25
    • MGC10540
    • Vacuolar protein sorting 25 homolog (S. cerevisiae)
    • Vacuolar protein sorting associated protein 25
    • Vacuolar protein-sorting-associated protein 25
    • VPS25
    • VPS25_HUMAN
    see all
  • Function
    Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
  • Tissue specificity
    Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung.
  • Sequence similarities
    Belongs to the VPS25 family.
  • Cellular localization
    Cytoplasm. Endosome membrane. Nucleus > nucleoplasm. Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.
  • Information by UniProt

References

ab45840 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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