The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 39 kDa.
Use a concentration of 3 - 6 µg/ml.
FunctionComponent of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Sequence similaritiesBelongs to the VPS37 family. Contains 1 VPS37 C-terminal domain.
Cellular localizationLate endosome membrane. Probably associates with membranes. Recruited to the plasma membrane by HIV-1.