Anti-VPS37D antibody (ab122683)
Key features and details
- Rabbit polyclonal to VPS37D
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-VPS37D antibody -
Description
Rabbit polyclonal to VPS37D -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence: LRDLLQDEPK LDRIVRLSRK FQGLQLEREA CLASNYALAK ENLALRPRLE MGRAALAIKY QELREVAENC ADKLQRLEES MHRWSPHC, corresponding to amino acids 27-114 of Human VPS37D.
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Positive control
- IHC: Human liver tissue. ICC/IF: Human cell line SH-SY5Y.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab122683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
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Notes |
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IHC-P
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
Target
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Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. -
Involvement in disease
Note=VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. -
Sequence similarities
Belongs to the VPS37 family.
Contains 1 VPS37 C-terminal domain. -
Cellular localization
Late endosome membrane. - Information by UniProt
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Database links
- Entrez Gene: 155382 Human
- Omim: 610039 Human
- SwissProt: Q86XT2 Human
- Unigene: 647037 Human
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Alternative names
- ESCRT-I complex subunit VPS37D antibody
- MGC35352 antibody
- Vacuolar protein sorting-associated protein 37D antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab122683 has not yet been referenced specifically in any publications.