Overview

  • Product name
    Anti-VPS37D antibody
  • Description
    Rabbit polyclonal to VPS37D
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: LRDLLQDEPK LDRIVRLSRK FQGLQLEREA CLASNYALAK ENLALRPRLE MGRAALAIKY QELREVAENC ADKLQRLEES MHRWSPHC, corresponding to amino acids 27-114 of Human VPS37D.

  • Positive control
    • Human liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
  • Involvement in disease
    Note=VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • Sequence similarities
    Belongs to the VPS37 family.
    Contains 1 VPS37 C-terminal domain.
  • Cellular localization
    Late endosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ESCRT-I complex subunit VPS37D antibody
    • MGC35352 antibody
    • Vacuolar protein sorting-associated protein 37D antibody
    • VP37D_HUMAN antibody
    • VPS37D antibody
    • WBSCR24 antibody
    • Williams-Beuren syndrome chromosomal region 24 protein antibody
    see all

Images

  • ab122683, at 1/20 dilution, staining VPS37D in paraffin-embedded Human liver tissue by Immunohistochemistry.

References

ab122683 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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