Overview

  • Product nameAnti-VRL1 antibody
    See all VRL1 primary antibodies
  • Description
    Rabbit polyclonal to VRL1
  • Tested applicationsSuitable for: Dot blot, IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide:

    CKNSASEEDHLPLQVLQSP

    (Rat) conjugated to KLH by a Glutaraldehyde linker.

  • General notesThis antibody is excellent for immunohistochemistry and western blot. VRL 1 is also known as Vanilloid Receptor Like protein-1.

Properties

Applications

Our Abpromise guarantee covers the use of ab6183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot Use at an assay dependent concentration.
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml.

Target

  • FunctionCalcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
  • Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
    Contains 6 ANK repeats.
  • Post-translational
    modifications
    N-glycosylated.
    Phosphorylated by PKA.
  • Cellular localizationCell membrane. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC12549 antibody
    • Osm 9 like TRP channel 2 antibody
    • Osm-9-like TRP channel 2 antibody
    • OTRPC2 antibody
    • Sac2b antibody
    • Stretch activated channel 2B antibody
    • Transient receptor potential cation channel subfamily V member 2 antibody
    • TRPV2 antibody
    • TRPV2_HUMAN antibody
    • Vanilloid receptor like protein 1 antibody
    • Vanilloid receptor-like protein 1 antibody
    • VRL 1 antibody
    • VRL antibody
    • VRL-1 antibody
    • VRL1 antibody
    see all

References for Anti-VRL1 antibody (ab6183)

This product has been referenced in:
  • Shimohira D  et al. TRPV2 expression in rat oral mucosa. Histochem Cell Biol 132:423-33 (2009). IHC-FoFr ; Rat . Read more (PubMed: 19579031) »
  • Yamamoto Y  et al. Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells. Neurosci Lett 454:129-33 (2009). IHC-Fr ; Rat . Read more (PubMed: 19429069) »

See all 3 Publications for this product

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Thank you for your enquiry. The concentration of this antibody is 1 mg/ml. Please contact us again if you have any additional questions.

The concentration is 1 mg/ml.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"