Anti-WAPL antibody [EPR3407(2)] (ab109537)

Overview

• Product nameAnti-WAPL antibody [EPR3407(2)]
  See all WAPL primary antibodies
• Description
  Rabbit monoclonal [EPR3407(2)] to WAPL
• Tested applicationsSuitable for: WB, IP, ICC/IFmore details
  Unsuitable for: Flow Cyt or IHC-P
• Species reactivity
  Reacts with: Human
  
• Immunogen

  A synthetic peptide corresponding to residues in Human WAPL.

• Positive control
  • HeLa, 293T, and Jurkat cell lysates. HeLa cells.
• General notes

  This product is a recombinant rabbit monoclonal antibody.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Produced using Abcam's RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5, 675, 063 and/or 7, 429, 487.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at -20ºC.
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• PurityTissue culture supernatant
• ClonalityMonoclonal
• Clone numberEPR3407(2)
• IsotypeIgG
• Research areas
  • Cell Biology
  • Cell Cycle
  • Cell Division
  • Chromatid Cohesion

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Chromosome Structure
  • Chromatid Cohesion

Associated products

• Positive Controls
  • HeLa nuclear extract lysate (ab14655)
  • Jurkat cytoplasmic extract lysate (ab14842)

Applications

Target

• FunctionRegulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
• Tissue specificityIsoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
• Sequence similaritiesContains 1 WAPL domain.
• Cellular localizationNucleus and Nucleus. Chromosome. Cytoplasm. Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

• Target information above from: UniProt accession Q7Z5K2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 23063 Human
  • Omim: 610754 Human
  • SwissProt: Q7Z5K2 Human
  • Unigene: 203099 Human
  • Unigene: 714876 Human
• Alternative names
  • FOE antibody
  • Friend of EBNA2 (Epstein Barr virus nuclear protein 2) antibody
  • Friend of EBNA2 protein antibody

  • KIAA0261 antibody
  • OTTHUMP00000020004 antibody
  • WAPAL antibody
  • WAPL antibody
  • WAPL_HUMAN antibody
  • Wings apart like homolog antibody
  • Wings apart like homolog (Drosophila) antibody
  • Wings apart-like protein homolog antibody

  see all