• Product name
  • Description
    Rabbit polyclonal to WAVE 1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide:


    conjugated to KLH, corresponding to C terminal amino acids 540-559 of Human WAVE 1

  • Positive control
    • Rat and mouse brain cytosolic fractions.



Our Abpromise guarantee covers the use of ab50356 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: Use at a concentration of 0.2 - 0.4 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 62 kDa). Staining of the WAVE band is specifically
    inhibited with the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
    • Tissue specificity
      Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
    • Sequence similarities
      Belongs to the SCAR/WAVE family.
      Contains 1 WH2 domain.
    • Domain
      Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
    • Cellular localization
      Cytoplasm > cytoskeleton. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
    • Information by UniProt
    • Database links
    • Alternative names
      • WASP family, verprolin homology domain-containing protein 1 antibody
      • WASP family member 1 antibody
      • FLJ31482 antibody
      • homology of dictyostelium scar 1 antibody
      • KIAA0269 antibody
      • Protein WAVE-1 antibody
      • Protein WAVE1 antibody
      • scar, Dictyostelium, homology of, 1 antibody
      • SCAR1 antibody
      • Similar to a plant extensin like protein antibody
      • Verprolin homology domain containing protein 1 antibody
      • Verprolin homology domain-containing protein 1 antibody
      • WAS protein family, member 1 antibody
      • Wasf1 antibody
      • WASF1_HUMAN antibody
      • WASL antibody
      • WASP family 1 antibody
      • WASP family protein member 1 antibody
      • WASP family, verprolin homology domain-containing protein antibody
      • WAVE antibody
      • WAVE1 antibody
      • Wiskott Aldrich syndrome protein family member 1 antibody
      • Wiskott-Aldrich syndrome protein family member 1 antibody
      see all


    • All lanes : Anti-WAVE 1 antibody (ab50356) at 1/4000 dilution

      Lane 1 : Mouse brain (cytosolic fraction S1)
      Lane 2 : : Rat brain (cytosolic fraction S1)
      Lane 3 : : Rat brain (cytosolic fraction S1) with immunizing peptide at 20 µg/ml

      Goat Anti-Rabbit IgG, Peroxidase conjugate
      Developed using the ECL technique

      Predicted band size : 62 kDa
      Observed band size : 75 kDa (why is the actual band size different from the predicted?)


    This product has been referenced in:
    • Payne LJ  et al. p53 Down Regulates PDGF-Induced Formation of Circular Dorsal Ruffles in Rat Aortic Smooth Muscle Cells. PLoS One 9:e108257 (2014). WB . Read more (PubMed: 25247424) »
    • Nascimento DS  et al. Satellite Glial Cells Surrounding Primary Afferent Neurons Are Activated and Proliferate during Monoarthritis in Rats: Is There a Role for ATF3? PLoS One 9:e108152 (2014). WB . Read more (PubMed: 25247596) »

    See all 3 Publications for this product

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