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FunctionDownstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Tissue specificityHighly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
Sequence similaritiesBelongs to the SCAR/WAVE family. Contains 1 WH2 domain.
DomainBinds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Cellular localizationCytoplasm > cytoskeleton. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using ab59281 at a dilution of 1/50. Left hand image - without immunizing peptide; right hand image - with immunizing peptide.
References for Anti-WAVE 1 antibody (ab59281)
has not yet been referenced specifically in any publications.
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