Anti-WAVE 1 (phospho Y125) antibody (ab59280)

Overview

  • Product nameAnti-WAVE 1 (phospho Y125) antibody
    See all WAVE 1 primary antibodies
  • Description
    Rabbit polyclonal to WAVE 1 (phospho Y125)
  • SpecificityDetects endogenous levels of WAVE1 only when phosphorylated at tyrosine 125.
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic phosphopeptide derived from human WAVE1 around the phosphorylation site of tyrosine 125 (E-T-YP-D-V).

  • Positive control
    • Human colon carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab59280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionDownstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
  • Tissue specificityHighly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
  • Sequence similaritiesBelongs to the SCAR/WAVE family.
    Contains 1 WH2 domain.
  • DomainBinds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
  • Cellular localizationCytoplasm > cytoskeleton. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
  • Information by UniProt
  • Database links
  • Alternative names
    • WASP family, verprolin homology domain-containing protein 1 antibody
    • WASP family member 1 antibody
    • FLJ31482 antibody
    • homology of dictyostelium scar 1 antibody
    • KIAA0269 antibody
    • Protein WAVE-1 antibody
    • Protein WAVE1 antibody
    • scar, Dictyostelium, homology of, 1 antibody
    • SCAR1 antibody
    • Similar to a plant extensin like protein antibody
    • Verprolin homology domain containing protein 1 antibody
    • Verprolin homology domain-containing protein 1 antibody
    • WAS protein family, member 1 antibody
    • Wasf1 antibody
    • WASF1_HUMAN antibody
    • WASL antibody
    • WASP family 1 antibody
    • WASP family protein member 1 antibody
    • WASP family, verprolin homology domain-containing protein antibody
    • WAVE antibody
    • WAVE1 antibody
    • Wiskott Aldrich syndrome protein family member 1 antibody
    • Wiskott-Aldrich syndrome protein family member 1 antibody
    see all

Anti-WAVE 1 (phospho Y125) antibody images

  • Ab59280 at 1/50 dilution staining human colon carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.

References for Anti-WAVE 1 (phospho Y125) antibody (ab59280)

ab59280 has not yet been referenced specifically in any publications.

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