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Function
May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
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Tissue specificity
Highly expressed in brain and heart. Weakly expressed in kidney, liver, lung and spleen.
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Pathway
Protein modification; protein glycosylation.
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Involvement in disease
Note=WBSCR17 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
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Sequence similarities
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Contains 1 ricin B-type lectin domain.
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Domain
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
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Cellular localization
Golgi apparatus membrane.
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Information by UniProt
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Database links
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Alternative names
- GalNAc-T-like protein 3 antibody
- GALNT16 antibody
- GALNT20 antibody
- GALNTL3 antibody
- GLTL3_HUMAN antibody
- Polypeptide GalNAc transferase-like protein 3 antibody
- Polypeptide N acetylgalactosaminyltransferase WBSCR17 antibody
- pp GalNAc transferase 20 antibody
- pp-GaNTase-like protein 3 antibody
- Protein-UDP acetylgalactosaminyltransferase-like protein 3 antibody
- Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
- UDP GalNAc:polypeptide N acetylgalactosaminyltransferase like 3 antibody
- UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 16 antibody
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
- Wbscr17 antibody
- Williams Beuren syndrome chromosome region 17 antibody
- Williams-Beuren syndrome chromosomal region 17 protein antibody
see all