Anti-WBSCR17 antibody (ab121403)

Overview

• Product name
  Anti-WBSCR17 antibody
  See all WBSCR17 primary antibodies
• Description
  Rabbit polyclonal to WBSCR17
• Tested applications
  Suitable for: IHC-P, WBmore details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  antigen sequence, corresponding to amino acids 29-126 (RPIAVRSGDA FHEIRPRAEV ANLSAHSASP IQDAVLKRLS LLEDIVYRQL NGLSKSLGLI EGYGGRGKGG LPATLSPAEE EKAKGPHEKY GYNSYLSE) of Human WBSCR17.

  Run BLAST with Run BLAST with
• Positive control
  • Human hippocampus tissue; RT-4 and U-251 MG cell lysates; Human liver and tonsil tissue lysates.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  pH: 7.20
  Preservative: 0.02% Sodium azide
  Constituents: 59% PBS, 40% Glycerol
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Protein Trafficking
  • Golgi Proteins

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• Function
  May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
• Tissue specificity
  Highly expressed in brain and heart. Weakly expressed in kidney, liver, lung and spleen.
• Pathway
  Protein modification; protein glycosylation.
• Involvement in disease
  Note=WBSCR17 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
• Sequence similarities
  Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
  Contains 1 ricin B-type lectin domain.
• Domain
  There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
• Cellular localization
  Golgi apparatus membrane.

• Target information above from: UniProt accession Q6IS24 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 64409 Human
  • Entrez Gene: 212996 Mouse
  • Entrez Gene: 288611 Rat
  • Omim: 615137 Human
  • SwissProt: Q6IS24 Human
  • SwissProt: Q7TT15 Mouse
  • Unigene: 488591 Human
• Alternative names
  • GalNAc-T-like protein 3 antibody
  • GALNT16 antibody
  • GALNT20 antibody

  • GALNTL3 antibody
  • GLTL3_HUMAN antibody
  • Polypeptide GalNAc transferase-like protein 3 antibody
  • Polypeptide N acetylgalactosaminyltransferase WBSCR17 antibody
  • pp GalNAc transferase 20 antibody
  • pp-GaNTase-like protein 3 antibody
  • Protein-UDP acetylgalactosaminyltransferase-like protein 3 antibody
  • Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
  • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase like 3 antibody
  • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 16 antibody
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
  • Wbscr17 antibody
  • Williams Beuren syndrome chromosome region 17 antibody
  • Williams-Beuren syndrome chromosomal region 17 protein antibody

  see all

Protocols

• Western blot protocols
• Immunohistochemistry protocols