Overview

  • Product name
    Anti-WBSCR17 antibody
  • Description
    Rabbit polyclonal to WBSCR17
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    antigen sequence, corresponding to amino acids 29-126 (RPIAVRSGDA FHEIRPRAEV ANLSAHSASP IQDAVLKRLS LLEDIVYRQL NGLSKSLGLI EGYGGRGKGG LPATLSPAEE EKAKGPHEKY GYNSYLSE) of Human WBSCR17.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human hippocampus tissue; RT-4 and U-251 MG cell lysates; Human liver and tonsil tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab121403 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function
    May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
  • Tissue specificity
    Highly expressed in brain and heart. Weakly expressed in kidney, liver, lung and spleen.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Note=WBSCR17 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • Sequence similarities
    Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • Domain
    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • GalNAc-T-like protein 3 antibody
      • GALNT16 antibody
      • GALNT20 antibody
      • GALNTL3 antibody
      • GLTL3_HUMAN antibody
      • Polypeptide GalNAc transferase-like protein 3 antibody
      • Polypeptide N acetylgalactosaminyltransferase WBSCR17 antibody
      • pp GalNAc transferase 20 antibody
      • pp-GaNTase-like protein 3 antibody
      • Protein-UDP acetylgalactosaminyltransferase-like protein 3 antibody
      • Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
      • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase like 3 antibody
      • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 16 antibody
      • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
      • Wbscr17 antibody
      • Williams Beuren syndrome chromosome region 17 antibody
      • Williams-Beuren syndrome chromosomal region 17 protein antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WBSCR17 antibody (ab121403)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WBSCR17 antibody (ab121403)
      ab121403 at 1/35 dilution staining WBSCR17 in paraffin-embedded Human hippocampus tissue by Immunohistochemistry.
    • Western blot - Anti-WBSCR17 antibody (ab121403)
      Western blot - Anti-WBSCR17 antibody (ab121403)
      All lanes : Anti-WBSCR17 antibody (ab121403) at 1/250 dilution

      Lane 1 : RT-4 cell lysate
      Lane 2 : U-251 MG cell lysate
      Lane 3 : Human plasma
      Lane 4 : Human liver tissue lysate
      Lane 5 : Human tonsil tissue lysate

      Developed using the ECL technique.

    References

    ab121403 has not yet been referenced specifically in any publications.

    Publishing research using ab121403? Please let us know so that we can cite the reference in this datasheet.

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