Overview

  • Product name
  • Description
    Rabbit polyclonal to WBSCR17
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    antigen sequence, corresponding to amino acids 29-126 (RPIAVRSGDA FHEIRPRAEV ANLSAHSASP IQDAVLKRLS LLEDIVYRQL NGLSKSLGLI EGYGGRGKGG LPATLSPAEE EKAKGPHEKY GYNSYLSE) of Human WBSCR17.

  • Positive control
    • Human hippocampus tissue; RT-4 and U-251 MG cell lysates; Human liver and tonsil tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab121403 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function
    May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
  • Tissue specificity
    Highly expressed in brain and heart. Weakly expressed in kidney, liver, lung and spleen.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Note=WBSCR17 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • Sequence similarities
    Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • Domain
    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GalNAc-T-like protein 3 antibody
    • GALNT16 antibody
    • GALNT20 antibody
    • GALNTL3 antibody
    • GLTL3_HUMAN antibody
    • Polypeptide GalNAc transferase-like protein 3 antibody
    • Polypeptide N acetylgalactosaminyltransferase WBSCR17 antibody
    • pp GalNAc transferase 20 antibody
    • pp-GaNTase-like protein 3 antibody
    • Protein-UDP acetylgalactosaminyltransferase-like protein 3 antibody
    • Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
    • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase like 3 antibody
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 16 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3 antibody
    • Wbscr17 antibody
    • Williams Beuren syndrome chromosome region 17 antibody
    • Williams-Beuren syndrome chromosomal region 17 protein antibody
    see all

Images

  • ab121403 at 1/35 dilution staining WBSCR17 in paraffin-embedded Human hippocampus tissue by Immunohistochemistry.
  • All lanes : Anti-WBSCR17 antibody (ab121403) at 1/250 dilution

    Lane 1 : RT-4 cell lysate
    Lane 2 : U-251 MG cell lysate
    Lane 3 : Human plasma
    Lane 4 : Human liver tissue lysate
    Lane 5 : Human tonsil tissue lysate

    Developed using the ECL technique

References

ab121403 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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