Genetic analysis of families with inherited pain disorders can help identify important insights into the human pain system
Join Dr. James Cox of UCL, in the first of a 2-part series on pain, as he reviews the methods used to identify genes underlying human monogenic pain disorders and discusses recent developments in our understanding of congenital insensitivity to pain.
The methods used to identify genes underlying human monogenic pain disorders
The diverse phenotypes associated with mutations in the Nav1.7 voltage-gated sodium channel
Recent developments in our understanding of congenital insensitivity to pain
As a post-doctoral researcher working with Professor Geoff Woods and Professor John Wood, he focused on SCN9A-associated Congenital Insensitivity to Pain and TRPA1-associated Familial Episodic Pain Syndrome, in addition to other human neurodevelopmental disorders.
James continues to work with families with inherited pain disorders to identify and understand the function of key novel genes in the pain system. He has a particular interest in the contribution of long non-coding RNA genes to pain pathways.