Human Predicted to work with:
Mouse, Rat, Monkey
KLH conjugated synthetic peptide, correponding to a region from an internal region of the Human WHIP protein. The immunogen sequence shows 100% homology to Human WHIP (isoform 1) and WHIP2 (isoform 2).
Human Kidney tissue
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionFunctions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
Tissue specificityUbiquitously expressed.
Sequence similaritiesBelongs to the AAA ATPase family. Contains 1 UBZ-type zinc finger.
Post-translational modificationsSumoylated by SUMO1 and SUMO2/3.
Cellular localizationNucleus. Colocalizes with WRN in granular structures in the nucleus.