Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab18729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 6 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 72 kDa.

Target

  • FunctionFunctions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the AAA ATPase family.
    Contains 1 UBZ-type zinc finger.
  • Post-translational
    modifications
    Sumoylated by SUMO1 and SUMO2/3.
  • Cellular localizationNucleus. Colocalizes with WRN in granular structures in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ATPase WRNIP 1 antibody
    • ATPase WRNIP1 antibody
    • bA420G6.2 antibody
    • FLJ22526 antibody
    • Putative helicase RUVBL antibody
    • RP11 420G6.2 antibody
    • Werner helicasae interacting protein 1 antibody
    • Werner helicasae interacting protein antibody
    • Werner helicase interacting protein isoform 2 antibody
    • Werner helicase-interacting protein 1 antibody
    • WRIP1_HUMAN antibody
    • WRNIP 1 antibody
    • WRNIP antibody
    • Wrnip1 antibody
    see all

Anti-WHIP antibody images

  • ab18729 (4µg/ml) staining of paraffin embedded Human Kidney following steamed antigen retrieval with Tris/EDTA buffer pH 9 and HRP-staining shows nuclear staining, stronger in DCT compared to PCT.

  • Anti-WHIP antibody (ab18729) at 1 µg/ml + Jurkat Cell Lysate in RIPA Buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 72 kDa

References for Anti-WHIP antibody (ab18729)

ab18729 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"