• Product nameAnti-WHSC1/NSD2 antibody
    See all WHSC1/NSD2 primary antibodies
  • Description
    Rabbit polyclonal to WHSC1/NSD2
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1315 and 1365 of Human WHSC1/NSD2 (NP_579877.1).

  • Positive control
    • HeLa whole cell lysate


Associated products


Our Abpromise guarantee covers the use of ab113258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionProbable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription.
    • Tissue specificityWidely expressed.
    • Involvement in diseaseNote=A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.
      Note=WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
    • Sequence similaritiesBelongs to the histone-lysine methyltransferase family. SET2 subfamily.
      Contains 1 AWS domain.
      Contains 1 HMG box DNA-binding domain.
      Contains 4 PHD-type zinc fingers.
      Contains 1 post-SET domain.
      Contains 2 PWWP domains.
      Contains 1 SET domain.
    • Post-translational
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm and Nucleus. Chromosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ23286 antibody
      • IL5 promoter REII region binding protein antibody
      • KIAA1090 antibody
      • MGC176638 antibody
      • MMSET antibody
      • MMSET type II antibody
      • Multiple myeloma SET domain containing protein type III antibody
      • Multiple myeloma SET domain protein antibody
      • Multiple myeloma SET domain-containing protein antibody
      • NSD 2 antibody
      • NSD2 antibody
      • NSD2_HUMAN antibody
      • Nuclear SET domain-containing protein 2 antibody
      • Probable histone-lysine N-methyltransferase NSD2 antibody
      • Protein trithorax-5 antibody
      • REIIBP antibody
      • Trithorax/ash1 related protein 5 antibody
      • TRX5 antibody
      • TRX5 protein antibody
      • WHS antibody
      • Whsc1 antibody
      • Wolf Hirschhorn syndrome candidate 1 antibody
      • Wolf Hirschhorn syndrome candidate 1 protein antibody
      • Wolf-Hirschhorn syndrome candidate 1 protein antibody
      see all

    Anti-WHSC1/NSD2 antibody images

    • ab113258 at 6ug/mg of lysate detecting WHSC1/NSD2 by immunoprecipitation (lane 1). 1mg of HeLa whole cell lysate was used, 20% of immunoprecipitate was loaded. Lane 2: IgG control.

    References for Anti-WHSC1/NSD2 antibody (ab113258)

    ab113258 has not yet been referenced specifically in any publications.

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