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Rabbit polyclonal to WHSC1/NSD2
Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 1060-1089 of Human WHSC1/NSD2 (NP_015627.1, NP_001035889.1).
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium azide
Constituent: 99% PBS
Concentration information loading...
Immunogen affinity purified
ab130701 is purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 152 kDa.
Probable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription.
Involvement in disease
Note=A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.
Note=WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
Belongs to the histone-lysine methyltransferase family. SET2 subfamily.
Contains 1 AWS domain. Contains 1 HMG box DNA-binding domain. Contains 4 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 2 PWWP domains. Contains 1 SET domain.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cytoplasm and Nucleus. Chromosome.
Information by UniProt
IL5 promoter REII region binding protein antibody
has not yet been referenced specifically in any publications.
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