For the best experience on the Abcam website please upgrade to a modern browser such as
Rabbit polyclonal to WHSC1/NSD2 - N-terminal
Synthetic peptide, corresponding to a region within N terminal amino acids 1-44 of Human WHSC1/NSD2.
MOLT4 and Raji cell lysates; A549 xenograft tissue.
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: 0.75% Glycine, 1.21% Tris, 10% Glycerol
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/300. Predicted molecular weight: 152 kDa.
1/100 - 1/1000. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
Probable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription.
Involvement in disease
Note=A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.
Note=WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
Belongs to the histone-lysine methyltransferase family. SET2 subfamily.
Contains 1 AWS domain. Contains 1 HMG box DNA-binding domain. Contains 4 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 2 PWWP domains. Contains 1 SET domain.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cytoplasm and Nucleus. Chromosome.
Information by UniProt
IL5 promoter REII region binding protein antibody
Western blot - Anti-WHSC1/NSD2 antibody - N-terminal (ab137429)
Anti-WHSC1/NSD2 antibody - N-terminal (ab137429) at 1/1000 dilution + Raji whole cell lysate at 30 µg
Predicted band size: 152 kDa 5% SDS PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WHSC1/NSD2 antibody - N-terminal (ab137429)
Immunohistochemical analysis of paraffin-embedded A549 xenograft tissue labelling WHSC1/NSD2 with ab137429 at 1/100 dilution.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"