Overview

  • Product name
  • Description
    Rabbit polyclonal to WISP1
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    CEDDAKRPRKTAPRDT

    conjugated to KLH, corresponding to N terminal amino acids 185-200 of Human WISP1

  • Positive control
    • Human hepatocarcinom tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab60114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Relevance
    WISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.
  • Cellular localization
    Secreted
  • Database links
  • Alternative names
    • CCN 4 antibody
    • CCN family member 4 antibody
    • CCN4 antibody
    • WISP 1 antibody
    • WISP 1c antibody
    • WISP 1i antibody
    • WISP 1tc antibody
    • WISP1c antibody
    • WISP1i antibody
    • WISP1tc antibody
    • WNT 1 induced secreted protein 1 antibody
    • Wnt 1 induced secreted protein antibody
    • WNT 1 inducible signaling pathway protein 1 antibody
    • Wnt 1 signaling pathway protein 1 antibody
    • Wnt-1 inducible signaling pathway protein 1 antibody
    • WNT1 induced secreted protein 1 antibody
    • Wnt1 induced secreted protein antibody
    • WNT1 inducible signaling pathway protein 1 antibody
    • Wnt1 signaling pathway protein 1 antibody
    • WNT1-inducible-signaling pathway protein 1 antibody
    see all

Images

  • Ab60114 (1/50-1/100) staining human WISP1 in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    HC = hepatocarcinoma.

References

This product has been referenced in:
  • Königshoff M  et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 119:772-87 (2009). Read more (PubMed: 19287097) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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