Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
Belongs to the Wnt family.
Secreted > extracellular space > extracellular matrix.
Han XR et al. MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic-ischaemic brain damage via the Wnt/ß-catenin signalling pathway. J Cell Mol MedN/A:N/A (2018).
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