Overview

  • Product name
  • Description
    Mouse polyclonal to Wnt4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Xenopus laevis
  • Immunogen

    Full length protein, corresponding to amino acids 1-351 of Human Wnt4 (Accession number: NP_110388.2; UniProt ID: P56705).

  • Positive control
    • Wnt4 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab169592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa.

Target

  • Function
    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
  • Involvement in disease
    Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]; also called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls.
    Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]; also known as SERKAL syndrome.
    Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL) [MIM:158330].
  • Sequence similarities
    Belongs to the Wnt family.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC123964 antibody
    • Protein Wnt-4 antibody
    • RP23-246F18.1 antibody
    • SERKAL antibody
    • Wingless type MMTV integration site family member 4 precursor antibody
    • WNT 4 antibody
    • WNT 4 protein precursor antibody
    • WNT4 antibody
    • WNT4_HUMAN antibody
    see all

Images

  • All lanes : Anti-Wnt4 antibody (ab169592) at 1 µg/ml

    Lane 1 : Wnt4 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    Goat anti-Mouse IgG HRP at 1/2500 dilution

    Predicted band size : 39 kDa

References

ab169592 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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