Overview

  • Product name
  • Description
    Rabbit polyclonal to Wnt7a
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Hamster, Cow, Dog, Pig, Chimpanzee, Gorilla, Elephant
  • Immunogen

    Synthetic peptide, corresponding to 10 amino acids from an internal region of Human Wnt7a (NP_004616.2).

  • Positive control
    • Human brain (cerebellum) tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab150592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.
  • Tissue specificity
    Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
  • Involvement in disease
    Defects in WNT7A are the cause of limb/pelvis-hypoplasia/aplasia syndrome (LPHAS) [MIM:276820]; also known as absence of ulna and fibula with severe limb deficiency. LPHAS is a limb-malformation disorder characterized by various degrees of limb aplasia/hypoplasia and joint dysplasia.
    Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS) [MIM:228930]; also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.
  • Sequence similarities
    Belongs to the Wnt family.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Protein Wnt-7a antibody
    • Protein Wnt-7a precursor antibody
    • Proto oncogene Wnt7a protein antibody
    • proto-oncogene wnt7a protein antibody
    • wingless-type MMTV integration site family, member 7A antibody
    • Wnt family member 7A antibody
    • WNT7A antibody
    • WNT7A_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain (cerebellum) tissue labeling Wnt7a with ab150592 at 5 µg/ml.

References

ab150592 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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