Overview

  • Product name
  • Description
    Mouse polyclonal to WSB1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human protein (entry NP_056441, aa 1-421)

  • Positive control
    • WSB1-transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab68953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 47 kDa (predicted molecular weight: 47 kDa).

Target

  • Relevance
    WSB1 is a member of the WD-protein subfamily. It shares a high sequence identity to mouse and chick proteins. It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus. It is a probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes type II iodothyronine deiodinase/DIO2. There are two named isoforms.
  • Cellular localization
    Intracellular
  • Database links
  • Alternative names
    • SOCS box containing WD protein SWiP 1 antibody
    • SWIP1 antibody
    • WD repeat and SOCS box containing 1 antibody
    • WD repeat and SOCS box containing protein 1 antibody
    • WSB 1 antibody
    see all

Images

  • All lanes : Anti-WSB1 antibody (ab68953) at 1/500 dilution

    Lane 1 : WSB1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

    Predicted band size : 47 kDa
    Observed band size : 47 kDa

References

This product has been referenced in:
  • Jia YY  et al. miR-592/WSB1/HIF-1a axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth. Oncotarget 7:35257-69 (2016). WB . Read more (PubMed: 27153552) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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