Anti-WWOX1 + 4 antibody (ab14691)

Overview

  • Product nameAnti-WWOX1 + 4 antibody
  • Description
    Rabbit polyclonal to WWOX1 + 4
  • SpecificityCross reacts with Wwox 1 and 4.
  • Tested applicationsSuitable for: WB, ELISA, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide, corresponding to C terminal amino acids 397-411 of Human WWOX1

Properties

Applications

Our Abpromise guarantee covers the use of ab14691 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 46 kDa.
ELISA 1/10000.
IHC-Fr Use at an assay dependent concentration.

Target

  • RelevanceWW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates 7 transcript variants, which encode different isoforms.
  • Cellular localizationCytoplasmic, Golgi Apparatus, Mitochondrial and Nuclear
  • Database links
  • Alternative names
    • FRA16D antibody
    • fragile site FRA16D oxidoreductase antibody
    • putative oxidoreductase antibody
    • WW domain-containing oxidoreductase antibody
    • WWOX antibody
    see all

References for Anti-WWOX1 + 4 antibody (ab14691)

ab14691 has not yet been referenced specifically in any publications.

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1. Sie bekommen 100ug von diesem Antikörper. Bei einer Konzentration von 0.57mg/ml bedeutet das, dass Sie 175ul bekommen. <...

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