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Overview

Product name

Anti-xCT antibody
See all xCT products (7) ...

Description

Rabbit polyclonal to xCT

Specificity

This antibody is specific for XCT.

Tested applications

WB, Flow Cyt, IHC-FoFrmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Synthetic peptide: MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL , corresponding to N terminal amino acids 1/50 of Human xCT

MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV

Positive control

human and mouse Stomach tissue lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: Tris glycine, 150mM Sodium chloride

Concentration

Concentration information loading...

Purity

Protein A purified

Purification notes

Affinity purified antibody.

Clonality

Polyclonal

Isotype

IgG

  • Western blot - xCT antibody (ab37185)Western blot - xCT antibody (ab37185) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab37185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 0.5 - 2 µg/ml.Predicted molecular weight: 55 kDa.( (ECL). )

  • ShowHide

    Flow Cyt

     Flow Cyt: Use at an assa...Read more →

    Flow Cyt: Use at an assay dependent dilution.

  • ShowHide

    IHC-FoFr

     IHC-FoFr: Use at an assa...Read more →

    IHC-FoFr: Use at an assay dependent dilution. (PubMed: 21639880)

Target

Function

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ9UPY5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Amino acid transport system xc xCT antibody antibody
  • Amino acid transport system xc- antibody
  • Calcium channel blocker resistance protein CCBR1 antibody
  • Calcium channel blocker resistance protein CCBR1 antibody antibody
  • CCBR1 antibody
  • Cysteine/glutamate transporter antibody antibody
  • cystine/glutamate transporter antibody
  • OTTHUMP00000164578 antibody
  • SLC7A11 antibody
  • Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody
  • solute carrier family 7 antibody
  • Solute carrier family 7 member 11 antibody
  • Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody
  • xCT antibody
  • XCT_HUMAN antibody
see all

Anti-xCT antibody images:

  Western blot - xCT antibody (ab37185)

Western blot - xCT antibody (ab37185)

All lanes : Anti-xCT antibody (ab37185) at 0.5 µg/ml

Lane 1 : Total human stomach lysate.
Lane 2 : Total mouse stomach lysate.

developed using the ECL technique

Predicted band size : 55 kDa
Observed band size : 55 kDa


Exposure time : 1 minute

Lysate loading concentration: 50µg

References for Anti-xCT antibody (ab37185)

This product has been referenced in:

  • Pampliega Oet al. Increased expression of cystine/glutamate antiporter in multiple sclerosis. J Neuroinflammation 8:63 (2011). WB, Flow Cyt, IHC-FoFr; Human, Mouse, Rat.Read more (PubMed: 21639880) »
  • Srivastava MKet al. Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res 70:68-77 (2010). Flow Cyt; Mouse.Read more (PubMed: 20028852) »

See all 3 publications for this product

Publishing research using ab37185? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"