Overview

  • Product nameXAV939
  • Description
    Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling.
  • Biological descriptionPotent tankyrase (TNKS) inhibitor. Inhibitor of Wnt/β-catenin signaling. (IC50 values are 11 and 4 nM for TNKS1 and 2, respectively). Inhibits TNKS PARP activity. Selectivity over other PARP enzymes and CRE, NK-κB and TGF-β.
  • Purity> 98%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120897 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    XAV939 images

    • ab16051 staining ß-catenin in SW480 cells treated with XAV939 (ab120897), by ICC/IF. Increase of ß-catenin cytoplasmic expression and decrease in nuclear expression correlates with increased concentration of XAV939, as described in literature.
      The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120897 (XAV939) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16051 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for XAV939 (ab120897)

    This product has been referenced in:
    • Sakata T & Chen JK Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways. Chem Soc Rev 40:4318-31 (2011). Read more (PubMed: 21505654) »
    • Karlberg T  et al. Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor. J Med Chem 53:5352-5 (2010). Read more (PubMed: 20565110) »
    • Huang SM  et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461:614-20 (2009). Read more (PubMed: 19759537) »

    See 1 Publication for this product

    Product Wall


    Unfortunately we do not routinely test all of our compounds in vivo so for these types of questions we have to rely on a literature search. I have done a quick search in the literature and on competitors and cannot see anything to suggest either w...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"