Overview

  • Product nameAnti-XBP1 antibodySee all XBP1 primary antibodies ...
  • Description
    Mouse monoclonal to XBP1
  • Tested applicationsELISA, WB more details
  • Species reactivity
    Reacts with: Human, Recombinant Fragment
  • Immunogen

    Recombinant XBP1 fragment (Human) (AAH12841, 123 a.a. ~ 225 a.a) with a tag.

  • Positive control
    • Hela NE cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab76443 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA Use at an assay dependent dilution.
WB 1/500 - 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 29 kDa).

Target

  • FunctionTranscription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.
  • Involvement in diseaseGenetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature.
  • Sequence similaritiesBelongs to the bZIP family.
    Contains 1 bZIP domain.
  • Cellular localizationNucleus.
  • Target information above from: UniProt accession P17861 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Tax responsive element binding protein 5 antibody
    • Tax-responsive element-binding protein 5 antibody
    • TREB5 antibody
    • X box binding protein 1 antibody
    • X box binding protein 2 antibody
    • X-box-binding protein 1 antibody
    • XBP 1 antibody
    • XBP-1 antibody
    • XBP1 antibody
    • XBP1_HUMAN antibody
    • XBP2 antibody
    see all

Anti-XBP1 antibody images

  • Anti-XBP1 antibody (ab76443) at 1/500 dilution + Recombinant protein at 0.2 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

    Predicted band size : 29 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-XBP1 antibody (ab76443) at 1/500 dilution + Hela NE cell lysate at 25 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 29 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

References for Anti-XBP1 antibody (ab76443)

ab76443 has not yet been referenced specifically in any publications.

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