Overview

  • Product nameAnti-xCT antibody
    See all xCT primary antibodies
  • Description
    Goat polyclonal to xCT
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse, Dog, Pig, Orangutan
  • Immunogen

    Synthetic peptide:

    C-KGQTQNFKDAFSGRD

    , corresponding to internal sequence amino acids 215-229 of Human xCT

  • Positive control
    • Human Spleen lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab60171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.02 - 0.06 µg/ml. Detects a band of approximately 52 kDa (predicted molecular weight: 55 kDa).

Target

  • FunctionSodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
  • Sequence similaritiesBelongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amino acid transport system xc xCT antibody antibody
    • Amino acid transport system xc- antibody
    • Calcium channel blocker resistance protein CCBR1 antibody
    • Calcium channel blocker resistance protein CCBR1 antibody antibody
    • CCBR1 antibody
    • Cysteine/glutamate transporter antibody antibody
    • Cystine/glutamate transporter antibody
    • OTTHUMP00000164578 antibody
    • SLC7A11 antibody
    • Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody
    • solute carrier family 7 antibody
    • Solute carrier family 7 member 11 antibody
    • Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody
    • SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN antibody
    • xCT antibody
    • XCT_HUMAN antibody
    see all

Anti-xCT antibody images

References for Anti-xCT antibody (ab60171)

This product has been referenced in:
  • Chintala S  et al. Downregulation of Cystine Transporter x(c) by Irinotecan in human head and neck cancer FaDu xenografts. Chemotherapy 56:223-33 (2010). Read more (PubMed: 20551639) »
  • Olm E  et al. Extracellular thiol-assisted selenium uptake dependent on the x(c)- cystine transporter explains the cancer-specific cytotoxicity of selenite. Proc Natl Acad Sci U S A 106:11400-5 (2009). WB ; Human . Read more (PubMed: 19549867) »

See all 2 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Rat Tissue lysate - other (Spinal cord)
Loading amount 20 µg
Specification Spinal cord
Treatment 4 hours after 300kdyne spinal cord injury
Gel Running Conditions Reduced Denaturing (4-20% Tris-HCl gel)
Blocking step Milk as blocking agent for 10 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 4°C
Username

Ms. Kelly Atkins

Verified customer

Submitted Oct 06 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"